RS 991:

How is the throttle response compared to the v8 in the cayenne s? Any lack at any RPM's?

Again, too early to tell very much.  My 2004 Cayenne S always had a lag or hesitation in the throttle response, a characteristic that I have written about extensively here on Rennteam.  So far I have not detected anything like that in the Macan; throttle response has been smooth and progressive with no hesitation.